I'm not going to be going specifically from the comic. It's going to be a little more inspired by that Marvel canon. I still want Sentinels, somthing like Nimrod, and government controlled mutants (I'm going to call them Hounds) that are used to round up there fellow mutants. I may event drop the term mutant and just make them Talents.
I'm planning on having the series start with the PCs already in an internment camp / prison and they are going to have to plan or participare in an escape, join or form a group or rebels, and wage guerilla war on the opressors.
I'm using the old Marvel Superheroes RPG MX adventures (find them here http://www.marvelrpg.net/mx/mx.html
) as a basis for what I am planning. I've always dug Days of Future Past and the Age of Apocolypse and I'm shooting for somthing in between.